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Cellular-scale, Injectable Electronics

Cellular-scale, Injectable Electronics Cellular-scale, injectable electronics consist of flexible filaments delivered by injection into the depths of targeted organs such as the brain. The most advanced devices consist of multilayered stacks of ultrathin active components, including wireless light emitting diodes that have dimensions comparable to those of a single cell. These systems can stimulate and monitor specific collections of neurons in the central and peripheral nervous systems, as means to elaborate connections to complex behavioral responses. The same concepts offer new capabilities in deep brain electrical stimulation, with further potential for application in other organs.  

Publications

Foundational publication:

T.-I. Kim, J.G. McCall, Y.H. Jung, X. Huang, E.R. Siuda, Y. Li, J. Song, Y.M. Song, H.A. Pao, R.-H. Kim, C. Lu, S.D. Lee, I.-S. Song, G. Shin, R. Al-Hasani, S. Kim, M.P. Tan, Y. Huang, F.G. Omenetto, J.A. Rogers and M.R. Bruchas, “Injectable, Cellular-Scale Optoelectronics with Applications for Wireless Optogenetics,” Science 240, 211-216 (2013)

Recent major publications:

G. Shin, A.M. Gomez, R. Al-Hasani, Y.R. Jeong, J. Kim, Z. Xie, A. Banks, S.M. Lee, S.Y. Han, C.J. Yoo, J.-L. Lee, S.H. Lee, J. Kurniawan, J. Tureb, Z. Guo, J. Yoon, S.-I. Park, S.Y. Bang, Y. Nam, M.C. Walicki, V.K. Samineni, A.D. Mickle, K. Lee, S.Y. Heo, J.G. McCall, T. Pan, L. Wang, X. Feng, T.-I. Kim, J.K. Kim, Y. Li, Y. Huang, R.W. Gereau IV, J.S. Ha, M.R. Bruchas and J.A. Rogers, “Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics,” Neuron 93, 509–521 (2017)

S.I. Park, G. Shin, J.G. McCall, R. Al-Hasani, A. Norris, L. Xia, D.S. Brenner, K.N. Noh, S.Y. Bang, D.L. Bhatti, K.-I. Jang, S.-K. Kang, A.D. Mickle, G. Dussor, T.J. Price, R.W. Gereau IV, M.R. Bruchas and J.A. Rogers, “Stretchable Multichannel Antennas in Soft Wireless Optoelectronic Implants for Optogenetics,” Proceedings of the National Academy of Sciences USA 113(50), E8169-E8177 (2016)

S.I. Park, D.S. Brenner, G. Shin, C.D. Morgan, B.A. Copits, H.U. Chung, M.Y. Pullen, K.N. Noh, S. Davidson, S.J. Oh, J. Yoon, K.-I. Jang, V.K. Samineni, M. Norman, J.G. Grajales-Reyes, S.K. Vogt, S.S. Sundaram, K.M. Wilson, J.S. Ha, R. Xu, T. Pan, T.-I. Kim, Y. Huang, M.C. Montana, J.P. Golden, M.R. Bruchas, R.W. Gereau and J.A. Rogers, “Soft, Stretchable, Fully Implantable Miniaturized Optoelectronic Systems for Wireless Optogenetics,” Nature Biotechnology 33(12), 1280-1286 (2015)

J.-W. Jeong, J.G. McCall, G. Shin, Y. Zhang, R. Al-Hasani, M. Kim, S. Li, J.Y. Sim, K.-I. Jang, Y. Shi, D.Y. Hong, Y. Liu, G.P. Schmitz, L. Xia, Z. He, P. Gamble, W.Z. Ray, Y. Huang, M.R. Bruchas and J.A. Rogers, “Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics,” Cell 162, 1–13 (2015)

R. Al-Hasani, J.G. McCall, G. Shin, A.M. Gomez, G.P. Schmitz, J.M. Bernardi, C.-O. Pyo, S.I. Park, C.M. Marcinkiewcz, N.A. Crowley, M.J. Krashes, B.B. Lowell, T.L. Kash, J.A. Rogers and M.R. Bruchas, “Distinct Subpopulations of Nucleus Accumbens Dynorphin Neurons Drive Aversion and Reward,” Neuron 87, 1063-1077 (2015)

Cover Articles

"Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring"

"Ultrathin Injectable Sensors of Temperature, Thermal Conductivity, and Heat Capacity for Cardiac Ablation Monitoring"

Ahyeon Koh, Sarah R. Gutbrod, Jason D. Meyers, Chaofeng Lu, Richard Chad Webb, Gunchul Shin, Yuhang Li, Seung-Kyun Kang, Yonggang Huang, Igor R. Efimov,* and John A. Rogers*

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"Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics"

"Fabrication and application of flexible, multimodal light-emitting devices for wireless optogenetics"

Jordan G McCall, Tae-il Kim, Gunchul Shin, Xian Huang, Yei Hwan Jung, Ream Al-Hasani, Fiorenzo G Omenetto, Michael R Bruchas, and John A Rogers

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