Bioresorbable Electronics
Bioresorbable electronic systems represent an emerging class of technology with potential to create important, new categories of devices with powerful modes of use in emergency medicine, recovery and rehabilitation. These systems are constructed entirely with materials that dissolve completely, with programmable rates after insertion into the body. Wide-ranging options in sensing, wireless data transmission, power supply and actuation are now possible in devices that exhibit excellent biocompatibility in cell level toxicity studies and animal trials. Systems with demonstrated utility in animal models include 'electroceuticals' for eliminating surgical site infections, temporary pacemakers for enhancing recovery from cardiac surgery, nerve and bone growth stimulators for accelerated healing and intracranial sensors for monitoring patients with traumatic brain injury. In these and other cases, the devices provide high performance, stable operation for a clinically relevant timeframe, and then completely resorb to eliminate unnecessary device load on the body in a manner that avoids risks associated with secondary surgical extraction.
Publications
Foundational publication:
S.-W. Hwang, H. Tao, D.-H. Kim, H. Cheng, J.-K. Song, E. Rill, M.A. Brenckle, B. Panilaitis, S.M. Won, Y.-S. Kim, Y.M. Song, K.J. Yu, A. Ameen, R. Li, Y. Su, M. Yang, D.L. Kaplan, M.R. Zakin, M.J. Slepian, Y. Huang, F.G. Omenetto and J.A. Rogers, “A Physically Transient Form of Silicon Electronics,” Science 337, 1640-1644 (2012)
Recent major publications:
K.J. Yu, D. Kuzum, S.-W. Hwang, B.H. Kim, H. Juul, N.H. Kim, S.M. Won, K. Chiang, M. Trumpis, A.G. Richardson, H. Cheng, H. Fang, M. Thompson, H. Bink, D. Talos, K.J. Seo, H.N. Lee, S.-K. Kang, J.-H. Kim, J.Y. Lee, Y. Huang, F.E. Jensen, M.A. Dichter, T.H. Lucas, J. Viventi, B. Litt and J.A. Rogers, “Bioresorbable Silicon Electronics for Transient Spatiotemporal Mapping of Electrical Activity from the Cerebral Cortex,” Nature Materials 15, 782-791 (2016)
S.-K. Kang, R.K.J. Murphy, S.-W. Hwang, S.M. Lee, D.V. Harburg, N.A. Krueger, J. Shin, P. Gamble, H. Cheng, S. Yu, Z. Liu, J.G. McCall, M. Stephen, H. Ying, J. Kim, G. Park, R.C. Webb, C.H. Lee, S. Chung, D.S. Wie, A.D. Gujar, B. Vemulapalli, A.H. Kim, K.-M. Lee, J. Cheng, Y. Huang, S.H. Lee, P.V. Braun, W.Z. Ray and J.A. Rogers, “Bioresorbable Silicon Electronic Sensors for the Brain,” Nature 530, 71–76 (2016)
C.H. Lee, H. Kim, D.V. Harburg, G. Park, Y. Ma, T. Pan, J.S. Kim, N.Y. Lee, B.H. Kim, K.-I. Jang, S.-K. Kang, Y. Huang, J. Kim, K.-M. Lee, C. Leal and J.A. Rogers, “Biological Lipid Membranes for On-Demand, Wireless Drug Delivery from Thin, Bioresorbable Electronic Implants,” NPG Asia Materials 7, e227; doi:10.1038/am.2015.114 (2015)
L. Yin, C. Bozler, D.V. Harburg, F. Omenetto and J.A. Rogers, “Materials and Fabrication Sequences for Water Soluble Silicon Integrated Circuits at the 90 nm Node,” Applied Physics Letters 106, 014105 (2015). doi: 10.1063/1.4905321
H. Tao, S.-W. Hwang, B. Marelli, B. An, J.E. Moreau, M. Yang, M.A. Brenckle, S. Kim, D.L. Kaplan, J.A. Rogers and F.G. Omenetto, “Silk-based Resorbable Electronic Devices for Remotely Controlled Therapy and In Vivo Infection Abatement,” Proceedings of the National Academy of Sciences USA 111(49), 17385–17389 (2014)
Cover Articles
"Thermally Triggered Degradation of Transient Electronic Devices"
Chan Woo Park, Seung-Kyun Kang, Hector Lopez Hernandez, Joshua A. Kaitz, Dae Seung Wie , Jiho Shin, Olivia P. Lee, Nancy R. Sottos, Jeffrey S. Moore, John A. Rogers, and Scott R. White*
View article"Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand"
Chi Hwan Lee, Jae-Woong Jeong, Yuhao Liu, Yihui Zhang, Yan Shi, Seung-Kyun Kang, Jeonghyun Kim, Jae Soon Kim, Na Yeon Lee, Bong Hoon Kim, Kyung-In Jang, Lan Yin, Min Ku Kim, Anthony Banks, Ungyu Paik, Yonggang Huang, and John A. Rogers*
View article"Biodegradable Thin Metal Foils and Spin-On Glass Materials for Transient Electronics"
Seung-Kyun Kang, Suk-Won Hwang, Sooyoun Yu, Jung-Hun Seo, Elise A. Corbin, Jiho Shin, Dae Seung Wie, Rashid Bashir, Zhenqiang Ma, and John A. Rogers*
View article"Mechanisms for Hydrolysis of Silicon Nanomembranes as Used in Bioresorbable Electronics"
Lan Yin, Amir Barati Farimani, Kyoungmin Min, Nandigana Vishal, Jasper Lam, Yoon Kyeung Lee, Narayana R. Aluru,* and John A. Rogers*
View article"A Physically Transient Form of Silicon Electronics"
Suk-Won Hwang, Hu Tao, Dae-Hyeong Kim, Huanyu Cheng, Jun-Kyul Song, Elliott Rill, Mark A. Brenckle, Bruce Panilaitis, Sang Min Won, Yun-Soung Kim, Young Min Song, Ki Jun Yu, Abid Ameen, Rui Li, Yewang Su, Miaomiao Yang, David L. Kaplan, Mitchell R. Zakin, Marvin J. Slepian, Yonggang Huang, Fiorenzo G. Omenetto, John A. Rogers
View article
